Determination and validation of aprepitant in rat plasma using LC−MS/MS

Erdoğar N, Reçber T , İskit A , Bilensoy E , Kır S & Nemutlu E | Bioanalysis, 13(5), 363 - 372, (2021) Keywords: • aprepitant • LC−MS/MS • pharmacokinetics • plasma • validation Aim: The assessment of efficacy should be paralleled with extensive pharmacokinetic parameters, and a valid bioanalytical method is a pre-condition for accurate plasma concentration. Materials & methods: A simple, specific, rapid and sensitive LC−MS/MS method has been developed for quantitative analysis of aprepitant in rat plasma. A C18 column was used as stationary phase and the mobile phase consisted of a mixture of formic acid in...