Could traditional mass-balance studies in the ‘twilight zone’ be improved by means of accelerator MS measurements?

“…when accelerated MS becomes a common and commercially available technique, it will no longer be restricted to microdose studies. Rather, it will contribute to and have a role in 14C macrodose studies…” The main objective of a traditional mass-balance study is to measure the difference between the excreted fraction and the administered amount of a drug. The second objective is to determine the routes of excretion. A standard procedure is to administer a single dose of the drug molecule labeled with 14C and to collect all urine and feces excreted for a certain period of time, which should correspond to...