Combining label-free technologies: discovery in strength

“...by combining several technologies one can leverage the strengths of the individual technology while avoiding the pitfalls.” Since the early 1990s when Biacore entered the market with the introduction of surface plasmon resonance (SPR) for use in elucidating interactions of proteins, label-free technologies have gained acceptance into all stages of drug discovery. The myriad of technologies now available to researchers allows for label-free methods to impact drug development from early discovery to entry into the clinic and beyond. However, each of these methods comes with its own advantages and disadvantages. While many of these methods can be used at several...