Challenges and advances in payload analysis for antibody-drug conjugates: a CRO perspective
Measuring payload molecules from antibody-drug conjugates (ADCs) requires sensitive analysis methods to measure their typical low concentrations in circulation. The examples presented in this article show that payload analyses and payload stabilities must always be evaluated in conjunction with the ADC present in the sample since a small impurity or a minor instability of the ADC can already lead to huge changes in free payload concentrations.
Challenges and Advances in payload analysis for ADCs_A CRO Perspective
‘Challenges and advances in payload analysis for antibody-drug conjugates’ is part of the Bioanalysis Zone Spotlight on ADC bioanalytics. Click here to view the full feature.
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