Emerging technologies: DMPK and bioanalysis of small molecules

In order to explore the key developments and technologies in this ever-evolving field, Bioanalysis Zone will be featuring a Spotlight on the emerging technologies in DMPK and the bioanalysis of small molecules. Small molecules play a key role in DMPK and bioanalysis, and are crucial to the discovery and developments of drugs. It is essential for scientists to develop more efficient, sensitive, robust and reliable methods and processes to qualitatively and quantitatively study these molecules.

This is made possible with the help of cutting-edge emerging technologies, allowing scientists to keep up with the rapidly advancing area. As part of this Spotlight, we will aim to cover a range of developments in novel techniques including:

  • Next generation ligand binding
  • Ion mobility–MS
  • Lab-on-a-chip
  • HRMS
  • Paper-based assays

This feature was produced in association with Waters and SCIEX.

Articles

Immediate drop on demand technology (I-DOT) coupled with mass spectrometry via an open port sampling interface
Advances in derivatization approaches for increasing the sensitivity of small molecules
Micro-SPE in pipette tips as a tool for analysis of small-molecule drugs in serum
Mass spectrometry in medicine: a technology for the future?
Small-molecule bioanalytical sample preparation method development starting from the BASICS
Bringing new technologies into regulatory space
Recent advances in liquid microextraction techniques coupled with MS for determination of small-molecule drugs in biological samples
Conference Report: The Conference on Small Molecule Science

Insights

An interview with Scott Summerfield: Emerging technologies in the bioanalytical field
Ion mobility spectrometry combined with high-resolution mass spectrometry: acquisition, analysis and application to drug metabolism studies
Paper-based dried sampling approaches for PK analysis: limitations and possibilities
Paper-based assays as useful tools for clinical bioanalysis
An author’s perspective: Zheng Ouyang on miniature mass spectrometry
An author’s perspective: Chris Zhu on MS-based metabolomics
An author’s perspective: Brendon Kapinos on LC/MS/MS-based screening
What are ion mobility MS and collision cross section data?
Poster: Can the routine use of ion mobility in drug metabolism studies aid with the efficient and robust characterisation of drugs and their metabolites?
Spotlight survey on emerging technologies: DMPK and bioanalysis of small molecules
An author’s perspective: Gary Van Berkel on immediate drop on demand technology coupled with mass spectrometry
Sciex: SelexION® differential mobility spectrometry
The science behind SelexION®DMS technology for quantitation
Reid Bioanalytical Forum 2017: Bioanalysis of the Future
2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV) (Part 1 – small molecules, peptides and small molecule biomarkers by LCMS)

Webinars

A new dimension in bioanalysis with SelexION differential mobility spectrometry
Expert insights into DMPK and bioanalysis of small molecules
Answering critical questions in biotransformation using mass spectrometry with routine ion mobility
Expert Series: Advancements in MALDI-TOF Mass Spectrometry towards Ultra High Throughput Screening

Interviews

An interview with Scott Summerfield: Emerging technologies in the bioanalytical field
From fundamental ion chemistry to differential mobility spectrometry: An interview with Larry Campbell from SCIEX
An author’s perspective: Brendon Kapinos on LC/MS/MS-based screening
Interview with Ian Moore (Sciex) on new technology to solve challenges in small and large molecule drug metabolism

Resources

Paper-based dried sampling approaches for PK analysis: limitations and possibilities
Emerging technologies: DMPK and bioanalysis of small molecules infographic
Integrating Ion Mobility into Routine Metabolite Identification Studies Using the Vion IMS QTof Mass Spectrometer
Poster: Can the routine use of ion mobility in drug metabolism studies aid with the efficient and robust characterisation of drugs and their metabolites?