Bioanalysis of biotherapeutics at a crossroad

“In these two special issues of Bioanalysis (Vol. 3 Issues 5 and 6), published in March 2011, the aim was to gather state-of-the-art considerations on the bioanalysis of biotherapeutics in order to help bioanalysts consider the advantages and limitations of available techniques." Bioanalysis in the pharmaceutical industry has become a real exciting challenge in the last few years. At the beginning of the decade, most of the drugs were low-molecular-weight compounds, the bioanalytical techniques of which were mastered by most analytical scientists. A long history of separative extraction, state-of-the-art extraction and LC processes, as well as recent development of ESI–MS...