An insight into the presence of impurities in reference standards and their impact on mass spectrometry-based bioanalysis

Ghoghari A , Patel H & Jain M | Bioanalysis, 14(18), 1191-1195, (2022) Keywords: • impurity • metabolite • reference standard Quantitative bioanalysis plays a crucial role in various stages of the drug discovery and development process. The efficacy and safety of a test drug or new chemical entity and its related metabolites can be gauged based on availability in the systemic circulation. Knowing levels of the drug or test compound or its metabolites in the blood circulation or targeted tissues is a key tool for optimizing biological activity, quantitative structure–activity relationships and biopharmaceutical properties. To meet these objectives, various...