A blood-based, metabolite and demographic characteristic markers panel for the diagnosis of Alzheimer’s disease

Yang L, Tan Q, Wenjing W, et al. | Bioanalysis, 15(20), 1247-1258, (2023) Keywords: • Alzheimer's disease • biomarker • diagnosis • metabolite Aims: This work was designed to provide early diagnosis strategies for Alzheimer's disease (AD) based on the identification of blood metabolic biomarkers. Patients & methods: A total of 90 subjects aged 60 years or older were included in this study; 45 patients were assigned to the case group and control group, respectively. A total of 31 target metabolites were quantitatively analyzed by parallel reaction monitoring between the two groups. Results & conclusion: Three metabolites were screened out, including cystine, serine and alanine/sarcosine. Logistic regression and random forest analysis were used...