International Women’s Day: A day in the life of…Lieve Dillen

Lieve Dillen
Senior Principal Scientist Bioanalysis

I joined the bioanalytical team at Janssen Research and Development in Beerse, Belgium in 2003 first as lead of the discovery bioanalysis team. Initially, the bioanalytical support involved quantitative analysis of ADME and PK/PD in discovery and preclinical projects.  Since April 2014, I joined the development bioanalytical team as lead of assay development. Since February 2016, more operational duties were included to my responsibilities. My scientific interest focuses on new technologies such as microsampling, HRMS, micro-LC, automation, quantification of new scaffolds with LC–MS with the goal to innovate and improve both science and efficiency in the bioanalytical lab.

 1My alarm goes off…

At 6.30am each morning (except the weekends), although I do not need an alarm. My biorhythm is programmed to start at the same hour every day. I never skip breakfast, I need some energy for the day. Breakfast is light with fresh fruits, yoghurt and milk. My goal is to leave home at 7.30am to start at work between 8 and 8.15am depending on traffic. Since last year all my kids left home so there is no stress in the morning. For 1 year I bought myself an e-bike which brings me to work in about an hour. The bike journey is very rural with winding roads across woods and in winter time too dark to embark. I am looking forward to Spring!

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2I’m responsible for…

All operational activities of the in-house bioanalytical team. Our internal team consists of about 10 bioanalysts working with LC–MS/MS. We support the quantitative analysis of preclinical non-GLP studies and the first-in-human studies for the development programs. Majority of the samples we analyse reside from internal customers.  Apart from the exposure of new drug candidates, also, the quantification of metabolites and biomarkers is requested. Upon selection of a new candidate drug for further development, we explore and develop a quantitative method that will be transferred to our external partners for support of the first-in-human preclinical safety package. Validation of the bioanalytical method and bioanalytical support of GLP studies is outsourced since 2016. Although the bioanalytical program scientists are responsible for all outsourced activities, transfer of the method and follow-up on the external method developing activities are part of my daily interactions.

3My typical day…

At work starts with a visit in the lab discussing results and issues with the lab technicians. This is often interrupted by meetings to discuss upcoming support for new projects. Also process related activities, preparing presentations, reports or manuscripts (or review of these documents) are part of my daily activities. Interactions with the bioanalytical scientists on their projects and with our external partners are often included in my schedule. Two days per week I try to have a 5-6 km run during lunch break with some colleagues.

4The best part of my job…

Is keeping all balls in the air, the planning of all studies, method development of challenging projects, implementation of new instruments and technology, interactions with peers, customers and partners, coaching and providing growth opportunities for my team, discussion on improving efficiencies.

5The worst part of my job…

The worst part of my job…is the time constraint and deadlines. But often challenging our customers when unrealistic deadlines are requested relieves part of the pressure.

6After work…

Working full time and raising 3 kids didn’t leave much time for extraordinary hobbies. However, as life progresses, I have now found more time for after-work activities. My husband and I love to travel, visit museums, going to the theatre and going out for dinner. I also have a fixed aerobic evening. A long wish list with literature for some good reading is always on my mind. However, currently I only manage good reading during holidays.

7I always wanted to be…

As a child, I dreamed to become a doctor or nurse to make a difference for people with a disease. Working at Janssen, I believe the new drugs we develop can make a better life for the patients.

Who is your inspirational hero?

No one in particular. All women who succeed in having a fulfilling career and are able (or lucky to be able) to combine it with a happy family life!