Microspray and microflow LC–MS/MS: the perfect fit for bioanalysis

“Looking to future, organizations will be looking for high-performance solutions that improve productivity and efficiency while maintaining workflows.” The advantages of microflow LC (MFLC) and nanoflow liquid chromatography coupled with a mass spectrometer are well known and include improved signal, low solvent consumption, reduced matrix effects and reduced source contamination [1]. In the past, microflow and nanoflow MS/MS have mainly been used in academic and fundamental research labs requiring high sensitivity analysis with limited sample volumes for qualitative or comparative analysis. The analytical advantages of low flow methods have led the technological development of specialized LC pumps that accurately deliver...