KCAS Bio

KCAS Bio is a leading contract research organization (CRO) employing top scientific talent which provides comprehensive bioanalytical services to the global biopharmaceutical industry from early discovery support through product registration and beyond. KCAS Bio offers bioanalytical, biomarker, immunogenicity, cellular and molecular assay services along with clinical kitting and sample management. KCAS Bio operates in state-of-the-art facilities in the United States and Europe, with the expertise, capacity, and flexibility to support the development of all types of drugs, biologics, cell and gene therapies to improve health worldwide.

FeaturesPostersVideosWebinarsIn the Zone

Addressing the key challenges and questions when deciding between old vs new technologies: a podcast with Franklin Spriggs (KCAS)

KCAS Bioanalytical and Biomarker Services appoints John Bucksath as new CEO

A Spotlight on immunogenicity: an interview with Joyce Slusser

Immunogenicity assay development

Emerging immuno-oncology therapies

KCAS Bioanalytical and Biomarker Services Appoints Dr. Abu Siddiqui as Director, Large Molecule & Biomarker Bioanalysis

KCAS Bioanalytical and Biomarker Services Appoints Dr. Joyce Slusser as Senior Scientist in Large Molecule Department

Panel Discussion: Hot Topics in Large Molecule Bioanalysis

Franklin Spriggs: validating bioanalytical methods for biomarkers

Application note: Development of an Anti-Drug Antibody Receptor Based Neutralizing Assay in Human Plasma

Application note: Modification of Commercial Kit Assay Conditions May Be Necessary for Increasing the Sensitivity of Biomarker Quantification: A Case Study

Immunogenicity services and capabilities at KCAS Bioanalytical & Biomarker Services

Types of anti-drug antibody regulated methods validated in the last 12 months at KCAS Bioanalytical & Biomarker Services

Development & Validation of a Direct Method for Quantification of DNA in Digested Tissue Samples

Fit-for-Purpose Anti-Drug Antibody (ADA) Assay: Cut Point is More Important than Lower Limit of Quantitation

Use of Dilutional Linearity as a Screening Tool in Selection of a Commercial Kit for Biomarker Quantification: A case study

Fit-for-Purpose Validation of a Soluble CD14 ELISA in Human Plasma: Anomalous Long-Term Stability Pattern for Endogenous Biomarker

Flow cytometric immunophenotyping of PBMCs and quantification of cytokine production from patients in a peptide vaccine study

John Bucksath (KCAS Bioanalytical & Biomarker Services) on ‘one stop shop’ laboratory services

Panel discussion: new technology integration in bioanalytical workflows

John Bucksath (KCAS Bioanalytical & Biomarker Services) on ‘one stop shop’ laboratory services

Panel discussion: the sharing of scientific data

Why flow cytometry at KCAS? Solving the mysteries of flow cytometry

The challenges of LC–MS bioanalytical methods: an interview with Lawrence Goodwin

Panel discussion: novel techniques and the new age of biomarkers

Panel discussion: gender parity in bioanalysis

Panel discussion: ICH M10 draft bioanalytical method validation guideline

Panel discussion: the evolution of flow cytometry

Panel discussion: strategies and challenges of immunogenicity

Panel discussion: what does the future hold for biomarker R&D?

Strategy for the selection and validation of your biomarkers for support of drug development

Types of anti-drug antibody regulated methods validated in the last 12 months at KCAS Bioanalytical & Biomarker Services

Immunogenicity: developing clinically relevant assays

In the Zone: alternative matrices

In the Zone: old vs new technologies

In the Zone: immuno-oncology

KCAS  Bio specializes in the following services:

Bioanalysis

  • Pharmacokinetics/ Toxicokinetics:
    • LC-MS/MS, Hybrid LC-MS/MS, LBA, qPCR, ddPCR
  • LNPs:
    • LC-MS/MS, Hybrid LC-MS/MS
  • Receptor occupancy:
    • Flow cytometry
  • Immunogenicity/ADA:
    • LBA
  • Biodistribution:
    • qPCR, ddPCR
  • Neutralizing antibodies assays:
    • Cell-based, plate based
  • Dose formulation analysis
    • SEC, UPLC

Pharmacodynamics

  • Primary endpoints
  • Functional assays
  • Secondary endpoints/ exploratory assays

Biomarkers

  • Soluble biomarkers:
    • LBA, qPCR, ddPCR, LC-MS/MS, MSD
  • Cellular biomarkers:
    • ELISpot, flow cytometry, qPCR, ddPCR, single-cell proteomics

Support

  • Formulation analysis
  • Sample kits (clinical/non clinical)
  • Bio-repository

Learn more at www.kcasbio.com or follow us on twitter @KCASBio

Website:
www.kcasbio.com

Email:
[email protected]

Telephone:
913-248-3000

Address:
10830 S Clay Blair Blvd
Olathe, Kansas
66061
USA